HMBA (Hydroxymethylbenzoic acid) is a useful and versatile benzyl ester derived linker, completely resistant to acids. The HMBA ChemMatrix® resin is easily cleavable by a variety of nucleophilic reagents like ammonia or primary amines (amides),1 hydrazine (hydrazides),2 methanol/triethylamine (methyl esters),3 sodium borohydride (alcohols) and sodium hydroxide (acids) to give access to peptides with diverse C-terminal functionalities.
Since the HMBA ChemMatrix® resin is TFA stable, on-resin side-chain deprotection can also be achieved. The HMBA ChemMatrix® resin can also be use in a new strategy suitable for the preparation of encoded one bead-one compound cyclic peptide library4.
Storage: +4°C , under dry and inert atmosphere
1. (a) Story, S. C.; Aldrich, J. V. Int. J. Peptide Protein Res., 1992, 39, 87-92; (b) Niu, J.; Lawrence, D. S. J. Biol. Chem., 1997, 272, 1493-1499; (c) Mohan, R.; Chou, Y.-L.; Morrissey, M. M. Tetrahedron Lett., 1996, 37, 3963-3966.
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